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Amgen (NASDAQ:AMGN) Stock Signal: How Will the Patent Cliff and Revenue Erosion from Biosimilars Impact Price Action?

By Adam Lemon
Chief Analyst and Director of Content

Adam Lemon began his role at DailyForex in 2013 when he was brought in as an in-house Chief Analyst. Adam trades Forex, stocks and other instruments in his own account. Adam believes that it is very possible for retail traders/investors to secure a positive return over time provided they limit their risks, follow trends, and persevere through short-term losing streaks – provided only reputable brokerages are used. He has previously worked with...

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Short Trade Idea

Enter your short position between $359.80 (yesterday’s intra-day low) and $364.72 (an intermediate horizontal resistance level).

Market Index Analysis

  • Amgen (NASDAQ:AMGN) is a member of the NASDAQ 100 Index, the Dow Jones Industrial Average Index, the S&P 100 Index, and the S&P 500 Index.

  • All four indices trade inside bearish price channels with decreasing bullish trading volumes.

  • The Bull Bear Power Indicator for the NASDAQ 100 Index turned bullish but remains below its descending trendline.

Market Sentiment Analysis

Equity futures point higher as markets await today’s Fed interest rate decision. While no change is expected, any comments regarding future monetary policy, especially after surging oil prices due to the Iran war, are likely to move markets. China granted NVIDIA approval to sell its second-most powerful AI chip, H200. On the earnings front, Micron Technology, General Mills, and Macy’s are on deck today.

Amgen Fundamental Analysis

Amgen is the 18th largest biomedical company by revenue, a Fortune 500 company, and has 17 clinical programs in Phase III, 8 in Phase II, and 19 in Phase I.

So, why am I bearish on AMGN following its breakdown?

I turned bearish on Amgen amid patent cliffs for Enbrel, Prolia, Xgeva, and Otezla that could wipe out between $8 and $ 10 billion in revenue over the next few years, while its current pipeline appears unable to offset these losses. Revenue erosion from its Biosimilars Prolia and Xgeva adds to revenue concerns, with CVS Health switching to lower-cost biosimilars in April 2026. Delays to its obesity drug MariTide and Merck‘s competition for Repatha add to my bearish outlook.

Metric
Value
Verdict
P/E Ratio
25.38
Bullish
P/B Ratio
22.80
Bearish
PEG Ratio
2.45
Bearish
Current Ratio
1.14
Bearish
ROIC-WACC Ratio
Positive
Bullish

Amgen Fundamental Analysis Snapshot

The price-to-earning (P/E) ratio of 25.38 makes AMGN an inexpensive stock. By comparison, the P/E ratio for the NASDAQ 100 Index is 36.27.

The average analyst price target for AMGN is $350.03. This suggests no upside potential with rising downside risks.

Amgen Technical Analysis

Today’s AMGN Signal

AMGN031826

Amgen Price Chart

  • The AMGN D1 chart shows price action inside a bearish price channel.

  • It also shows price action between its ascending 38.2% and 50.0% Fibonacci Retracement Fan levels.

  • The Bull Bear Power Indicator turned bearish with a descending trendline.

  • The average bearish trading volumes are higher than the average bullish trading volumes.

  • AMGN corrected with the NASDAQ 100 Index, which is a bearish trading signal.

My AMGN Short Stock Trade

  • AMGN Entry Level: Between $359.80 and $364.72

  • AMGN Take Profit: Between $303.82 and $312.39

  • AMGN Stop Loss: Between $381.89 and $391.29

  • Risk/Reward Ratio: 2.53

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Chief Analyst and Director of Content

Adam Lemon began his role at DailyForex in 2013 when he was brought in as an in-house Chief Analyst. Adam trades Forex, stocks and other instruments in his own account. Adam believes that it is very possible for retail traders/investors to secure a positive return over time provided they limit their risks, follow trends, and persevere through short-term losing streaks – provided only reputable brokerages are used. He has previously worked within financial markets over a 12-year period, including 6 years with Merrill Lynch.

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